Solute carriers (SLCs) are biologically important proteins that control movement of small molecules and ions across membranes. Drug classes that target SLCs include SSRIs and SGLT2 inhibitors. While the SLC family appears to be generally small molecule druggable and is similar in size to the Class A GPCRs, the number drug targets is currently around 10x fewer. The presentation will explore this apparent paradox and provide an overview of the current status of SLC drug discovery.

Solute carrier proteins as a source of new drug targets: Challenges and opportunities

ACS Spring 2022

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