The quinolizidine is a ubiquitous nitrogen heterocycle which serves as the core structure of several alkaloid natural products exhibiting inherent biological activity against an array of bacteria, fungi, viruses, and cancer cell lines. This azacycle serves as a key synthetic building block for medicinal chemists to access more structurally complex and diverse compounds with tunable biological properties. A synthetic approach to these valuable motifs employing borrowing hydrogen catalysis has been developed. The utility of the developed chemistry is demonstrated via synthetic efforts towards the recently isolated cylicomorphins A-E.

Access to the cylicomorphins A-E and other nitrogen heterocycles via borrowing hydrogen catalysis

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.