Mood and anxiety disorder are reported in patients with deificit in the somatostatin-positive GABA interneurons. Chronic stress is one of the principle cause for lowering SST+ GABA cellular phenotype across corticolimbic brain regions. Which causes depressive or anxiety like behaviors. The main goal is to find a way that can reverse this effect. Reversing the effect resembles the anti-depressant action. Compounds that can bind to the GABA receptor at the Alpha-5 subunit can reverse the effect. As a result the complexity of mood and anxiety disorder is solved. A mouse model was developed with a modified brain wide SST+ cells. The compound that was used is GL-II-73, which is PAM of GABA receptor at alpha 5 subunit.

Alpha-5 GABA-A receptor potentiation as a treatment for behavioral deficits

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.