Over the last several decades, a plethora of novel and innovative synthetic methods have been reported in the literature. Analytical characterization of these new reactions is of critical importance to determining success, though it can often be a very challenging and time-consuming task. Success in an industrial setting often requires close collaboration between synthetic chemists and analytical chemists, to ensure that the best analytical techniques are being applied properly to address the main questions of the work. This presentation will showcase the power of this collaboration by highlighting examples where analytical measurements played a key role. Frequently this requires a change from the established paradigm and requires either repurposing existing technology or developing novel platforms. Examples will be presented that span biocatalysis, crude reaction monitoring, and the assignment of absolute configuration to gain mechanistic understanding of several new reactions. Taken together, these examples highlight how the synergy between analytical and organic chemistry can lead to a deeper understand of organic synthesis.

Enabling organic synthesis through the development and application of novel analytical methods

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.