Rapid preparation of polysaccharides is by automated glycan assembly (AGA) [1] using a synthesizer [2]provides access to diverse glycans as large as 151-mers [3]. Microwave accelerated synthesis methods [4] are now used to synthesize ever more complex glycans including challenging <i>cis</i>-linked polysaccharides [5] are enabling fundamental investigations into the structure and function of polysaccharides.<br/>Synthetic glycans are key in combination with single molecule imaging, [6] molecular modelling and other physical methods to characterize carbohydrates. [7-9]. I will describe a next generation AGA synthesizer that is used to prepare complex N-glycans, sulfated glycans as well as glycopeptides.

Next generation automated glycan assembly for the rapid synthesis of complex polysaccharides and glycopeptides

ACS Spring 2022

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