Chiral hydroxamic acids have found many applications in such diverse areas as drug design and asymmetric organocatalysis. However, methods for their enantioselective synthesis are rather limited. On the other hand, many of them are easily obtainable in racemic form. Herein, we present the first kinetic resolution of racemic hydroxamic acids via catalytic, enantioselective O-acylation.

Kinetic resolution of cyclic hydroxamic acids via catalytic, enantioselective O-acylation

ACS Spring 2022

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