Nitric oxide (NO) is a vasodilator and can be used to increase blood flow to an area in need of tissue repair. Through the process of electrospinning, a patch was created to release NO which is composed of four layers. The patch consists of a layer of 9% (w/w) Tecophilic®(TP)/cellulose/ascorbic acid, two layers of TP/super absorbent polymer, and a layer of TP/Dowex-NO2. Based upon previous studies, the release of nitric oxide was found to be inconsistent. In collaboration with a neighboring university, a NOx analyzer was used to effectively quantify the patch. Based on the analysis, the most effective location of release was found to be the central quadrant of the patch. The amount of NO released decreased as the sample distance from the center increased. The use of additives to the patch was explored but produced mixed results.

Quantification of a nitric oxide releasing wound healing patch

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.