Carbon nanodots have recently gained attention as theranostics due to their ease of synthesis, inexpensive costs, versatility and high water solubility. Recent reports on <i>N-</i>acetylglucosamine functionalized carbon nanodots for selectively targeting bacteria inspired us to consider whether other sugars could be used to tune the properties and tumor targeting ability of these compounds towards cells that overexpress carbohydrate binding proteins. Here we present the synthesis of carbon nanodots using three different phenylenediamines and glucosamine, galactosamine, and mannosamine. We also provide insights into our initial cell studies with a HepG2 line.

Synthesis of carbohydrate-functionalized carbon nanodots for tumor targeting

ACS Spring 2022

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