Non-Heme Iron Halogenases (NH-Fe Hal) catalyze the halogenation of various substrates incuding amino acids, nucleotides and natural products with high regio- and chemo-selectivity. In this ACS talk, I will discuss our lab's recent work towards using rational and computational enzyme design methodologies to broaden the substrate and reaction promiscuity of NH-Fe Hal enzymes. Our research demonstrates how primary, secondary coordination sphere and protein-protein interactions can be rationally modulated in NH-Fe Hals to transform them into promiscous biocatalysts.

Substrate and reaction promiscuity of non-heme iron halogenases

ACS Spring 2022

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