Continuous Countercurrent Tangential Chromatography (CCTC) has been extensively evaluated for monoclonal antibody purification and has shown significant benefits including lower resin utilization (80%), improved product quality and process economics. In this presentation we will present brand new research showing the results of pilot for for AAV capture using the CCTC platform. CCTCshows significant improvements in productivitity (10-20X) as well as improved control of product quality, low residence time, improved recovery and robustness vs status quo column capture.  Co-currently with the technical presentation we will also discuss impact on process economics and process footprint.

Improved capture for AAV vector manufacturing using column-free continuous countercurrent tangential chromatography (CCTC)

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.