Catalase is one of the most efficient enzymes in biology and has been unmatched by benchtop methods thus far. The desired antioxidant activity of catalase for medical and industrial application has inspired the study of many iron mimics of the catalase activity. However, very few of these studies explored the impact of the metal center environment on the activity of the complex. In this study, pyclen type Fe (III) complexes were investigated as catalase mimics and the impact of the electronic properties (L1, L2 and L3) and the structural rigidity (L1 and L4) of the ligand were evaluated. Cyclic voltammetry, X-ray structural analysis and potentiometric titration were conducted to characterize and study the properties of the complexes. Kinetic studies following the initial rate method and TON studies were conducted to compare the activity of these complexes.

Study of electronic properties and structural rigidity on the activity of pyclen type Fe(III) complexes catalase mimics

ACS Spring 2022

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