Cyclotides are plant-based cyclic peptides containing six cysteine residues that form three disulfide bonds. Pharmaceutical properties, as well as insecticidal activities of cyclotides, have been reported. The present study describes the extraction and purification of cyclotides from Australian violet (<i>Viola hederacea</i>). A comparison of the extraction of cyclotides using traditional and deep eutectic solvents will be presented. Aggregation and self-assembly properties of cyclotides will also be described in various polarity liquids. The experimental aggregation study and molecular dynamics data will be used to guide the development of machine learning algorithms.

Extraction, purification, self-assembly, and aggregation studies of cyclotides

ACS Spring 2022

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