Tuberculosis (TB) continues to be a serious threat worldwide. Tb is one of the top ten causes of death from a single infectious agent. This disease is caused by the infection of <i>Mycobacterium tuberculosis</i>. Drug-resistant TB remains to be a great threat to public health, specifically for developing countries. Current treatment options are lengthy and can lead to undesirable side effects, as well as drug resistance from bacteria if not taken as prescribed. Developing novel drugs leading to improving current treatment options is highly demanding. Antimicrobial polymers that mimic naturally occurring antimicrobial peptides have gained much attentions owing to their unique antimicrobial mechanism of membrane integrity disruption. which is believed to disrupt the integrity of the bacterial cell membranes. Previously, our group discovered that positively charged polyguanylurea (PGU) exhibits high antimycobacterial efficacy. Herein, we will present detailed antimycobacterial mechanism of PGU-P-8K using <i>M. smegmatis</i> as a model organism for mycobacteria.

Mechanism studies of antimicrobial poly(guanylurea) 8K against Mycobacterium smegmatis>

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.