Given our current knowledge, organic chemists have the ability - granted unlimited time and resources – to make almost any organic scaffold. Thus the fundamental motivations in modern chemistry have shifted to the development of efficient processes that accelerate synthesis and reduce associated waste.1,2 Research in the Hull group focuses on the development and mechanistic evaluation of transition metal-catalyzed methodologies with the direct goal of reducing the time and waste associated with the synthesis of biologically active molecules. A common goal of all of our research is to strategically design new methodologies that either utilize or override the inherent reactivity of simple functionalities to generate desirable products. We aim to reduce multi-step sequences into single transformation on easily accessible starting materials to form complex products. Additionally, we seek to develop methodologies that allow access to a wide variety of derivatives from common synthetic intermediates, facilitating diversity orientated synthesis and accelerating structureactivity-relationship studies.<br/><br/>Despite the prevalence of C–N bonds in pharmaceuticals, their selective incorporation into organic compounds is often both time- and resource- consuming. The selective addition of nitrogen to a C=C multiple bond would allow for the single step installation of diverse functionalities from readily available starting materials. Given this potential versatility and utility, the development of intermolecular, regio-, chemo-, and stereoselective hydro-, oxidative, and carbo- amination reactions represents an unmet need in synthetic chemistry.

Transition metal-catalyzed amination reactions

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.