We have developed novel nanowire devices to actively control the behavior of single cells and cellular networks via external stimuli.  The wiring between cells is established with either inorganic nanowires or biowires comprising protein assemblies. The inorganic and biological nanowire arrays interface with many types of eukaryotic cells, and allow for the design of arrays that enable spatiotemporal control of a cellular network. In this talk, we emphasize inorganic NWs and present a novel fabrication method to conformally coat NWs with conductive polymers. Fluorescent cargos, doped in electroresponsive polymer matrix at wire tips, are released with fidelity upon the application of a potential. This hybrid polymer-semiconductor platform extends methods available for cellular cargo delivery with spatiotemporal control and links electrical signaling from artificial systems with living molecular transduction.

Spatiotemporal control of cellular cargo delivery

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.