We are exploring the relationship between interpersonal differences in gut microbiome and health benefits obtained from the consumption of common vegetables, legumes and whole-grains.  These foods represent major sources of fiber among US consumers and have been associated with protective effects against cardiometabolic disease (CMD). However, human studies have revealed a large degree of interpersonal variation in the effects associated with their consumption, with a subset of individuals not exhibiting any benefits.  Furthermore, we cannot currently predict who will benefit from their consumption.   I will discuss our studies in gnotobiotic mice transplanted with human communities that suggest that protection against CMD associated with consumption of these high-fiber diets is modulated by the gut microbiome, and the host responses associated with specific microbes and microbial metabolites derived from specific foods.

Gut microbiome variation influences host responses to diet

ACS Spring 2022

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