Our latest investigations on the development of catalytic methods for synthesizing heteroatom-functionalized building blocks and advanced drug-like molecules will be presented. The use of a family of simple P,N-ligandless complexes, with the general formula [Cp*Ir(III)] have been used for tandem 1,3-hydride shift / functionalization of allylic alcohols, as well as for halogenation and methylation of C–H bonds in benzoic acids. Our attempts to develop asymmetric halogenation reactions resulted on the development of a novel organocatalytic stereospecific reaction mediated by a simple base, and which relies on the <i>in situ</i> formation of ions pairs with induced non-covalent chirality. The scope as well as the mechanisms of these reactions will be discussed.

Selective construction of carbon–carbon and carbon–heteroatom bonds mediated by Cp*Ir(III) complexes

ACS Spring 2022

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