Development of effective commercially viable process analytical technology tools requires the interconnection of processing equipment and analytical tools with robust methods and reliable controls. Regardless of whether the process is intended to be continuous, semi-continuous or batch, automated process control and PAT can improve efficiency and product consistency in manufacturing. Here we demonstrate a system to control a TFF process based on concentration acquired via variable-pathlength spectroscopy. Real-time feedback of the concentration information from the variable pathlength spectrophotometer allows for adjustment of the feed-pump speed and the back-pressure valve. Samples were taken periodically during the process to compare to offline instrumentation. Automated process control is demonstrated for various final concentration end-points.

Variable pathlength control of TFF processes

ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.