ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

American Chemical Society

Current Topics in Biological Chemistry

Effects of site specific histone modifications on nucleosomal DNA accessibility

Predicting the impact of germ line mutations on protein DNA interactions

Composition and function of cartilage extracellular matrix

Employing solid phase synthesis to access nucleoside-containing small molecule inhibitors of phosphoglycosyl transferases

Characterizing large conformational changes in transcription initiation by E. coli RNA polymerase

Towards the synthesis of L-α-threofuranosyl nucleoside triphosphates and oligonucleotides with an expanded genetic alphabet

Nitroreductase-dependent generation of aza-quinone methides for alkylation of biological nucleophiles

Identification and characterisation of a dual GLP-1/GLP-2 agonist peptide, HTL0030023 using structure based drug design

In vitro antimicrobial activity of extracts of Montrichardia arborescens (Moco moco) stems and combined extract of Montrichardia arborescens stems and Azadirachta indica (Neem) leaves

Droplet evaporation induced analytes concentration toward sensitive biosensing

Three dimensional intact tissue transcriptional analysis of mouse spinal cord

Graphene oxide/Silver-based nanomaterials inhibit lentiviral infection

Investigating the impact of solvent on β-sheet forming peptide

Irreversible inhibitors of native Med25 PPIs

Mapping the structure and activity of the novel metalloenzyme Ste24 using peptide probes

Biomedical application and biochemical investigation of quadruplet codons decoding

Investigation into the inactive acyltransferase (AT) domain in module 2 and module 4 of the gephyronic acid biosynthesis

Non-native peptides capable of pan-activating the agr quorum sensing system across multiple specificity groups of Staphylococcus epidermidis

Stability of mixed chirality DNA

Modification of peptoid length and side-chain functionality to improve biological activity

Exploring the structure-function relationship in synthetic and bacterial melanin pigments

In vitro reconstitution of fimsbactin biosynthesis from Acinetobacter baumannii

Mechanistic investigation of flavonoid inhibitors of the bacterial fatty acid synthase enzyme enyol-ACP reductase

An analytical approach about cocrystals of levetiracetum and oxalic acid through H1 NMR AND C13 NMR

Targeted protein acetylation in cells using heterobifunctional molecules

Investigating the role of alkyl quinolone modifying vanadium-dependent haloperoxidases in microbial community modulation

Understanding the biochemical and biopysical properties of α-synuclein oligomers

Properties of in silico designed 3WJ DNA motif for nanoparticles assembly

Development of highly fluorogenic styrene-based probes for visualizing RNA in live cells

Toward cell-based protein tyrosine phosphatase activity assays

Neuro-magnetic induction: A hypothetical research

Bioengineering of a haloalkane dehalogenase for the bioremediation of perfluorinated compounds

Novel extended-spectrum antibiotic drug target for alanine racemase

Gene regulation using nanodiscs modified with HIF-1-α antisense oligonucleotides

Exploring the thioester intermediate capture strategy with polyktide synthetase

Improved red fluorescent redox indicators for monitoring cytosolic and mitochondrial thioredoxin redox dynamics

Discovery of antimicrobial peptides as multi-target inhibitors against amyloid aggregation and microbial infection

Effects of polyphenolic acids on amyloid fibril formation in the liquid phase using atomic force microscopy

Polydimethylsiloxane nerve guidance conduit with microchannels for peripheral nerve regeneration

Synthesis, characterization, and bioactivity of alloxan ethylthiosemicarbazone and its copper derivative as an undergraduate research project

Enzymatic synthesis of mycobacterial L,D-transpeptidase substrates

Design and synthesis of a photo cleavable bioconjugate probe for determining the composition of lipids in a nanodisc

Fluorescent properties of aurone-derived triazoles

Predicting pseudoknots in SARS-CoV-2 with ThreshKnot, ShapeKnots, and reactivity data

Molecular understanding and evidences of amyloid cross-seeding

Investigating uracil DNA glycosylase binding in nucleosome core particles

Identifying descriptors for predicting kinetic mutational effects of lactonase by integrating machine learning and atomistic simulations

Novel 13C hyperpolarized probes for assessing tricarboxylic acid cycle metabolism

Insights into the molecular details of O-glycoprotease substrate recognition and cleavage

Development of a model for bacterial antibiotic resistance in E. coli

Degradation of Med25 with peptide based PROTACs

Investigating the neutralizing properties of antibodies generated against an Aβ-derived oligomer: Efforts toward a novel Alzheimer’s disease immunotherapy

Chemical or radiological toxicity: Effects of uranium oxides on human lung cells

Antibody-coated nanoparticle attachment to Saccharomyces cerevisiae

Development of a coactivator-activator PPI inhibitor with modifiable target selectivity

Design, synthesis, and biological evaluation of Inhibitors of NADPH Oxidase 1, Nox1: Applications in medicinal chemistry

Understanding the role of metals in antimicrobial efficiency within model systems

Determining the effect of the sas-6(L69T) primary microcephaly-associated mutation on centrosome duplication in Caenorhabditis elegans

Protocol for the fabrication and assembly of centrifugal microfluidic devices

Mechanical properties of molecular dynamic simulated membranes

Semi-purified fraction of Tridax procumbens induces differentiation of mouse embryonic pancreas and enhances the population of liver progenitor cells

Teasing out effectors of assembly dynamics of the vertebrate lens: An investigation of charge, concentration, and polydispersity on lens homeostasis

New method to detect cancer biomarkers electrically using single-molecule techniques for liquid biopsy applications

Analysis of E. coli Nudix hydrolase knockout phenotypes: antimutator properties and antibiotic susceptibility

Investigation of active site architecture that dictates enzymatic activity of both mono- and diheme forms of MhuD, a heme oxygenase from Mycobacterium tuberculosis

What bugs the bug? Staphylococcus aureus specifically senses and responds to heparin

Resonance Raman studies of the oxygenated species involved in heme hydroxylation

Defining protein characteristics that drive phase separation

Studies on the mechanism, kinetics, and thermodynamics of desferrioxamine D

Hybrid living functional materials of zeolitic imidazolate framework for antibacterial and anti-tumor activity

Computational drug design of aromatase inhibitors as a treatment for endometriosis

Effectiveness of herbal extracts as arachidonate 15-lipoxygenase inhibitors

Novel metabolism of 5-nitroimidazole antibiotics by a human pathogen nitroreductase

Precise quantitative measurement of reactive nitrogen species

Optimizing the production yield and stability of the HK97 head II virus like particle produced from Escherichia coli

Characterization of triterpene synthases combined with metabolic profiling provides a comprehensive understanding of triterpene alcohol biosynthesis in tomato

Towards an integrated model of protein-DNA recognition through studies of the lac repressor headpiece

Structure-function correlation studies of canonical and noncanonical heme oxygenases

Optimizing and characterizing the synthesis of copper (I) complexes on resin as tyrosinase mimics

Antimicrobial effect of biologically synthesized copper sulfide nanoparticles

Mechanism of inhibition protein tyrosine phosphatase 1β (PTP1β) by terpenoids

Qualitative measurement of stability of ATP at varying pH using UV-Vis spectroscopy

Characterization of aptamer families for biosensing

Evaluation of atypical carbapenems against mycobacterial L,D-transpeptidases

Novel inhibitors of HIV viral infectivity factor using computational design and analysis

Detection of photoreceptor bistability and monostability: An assay

Reverse-demand voltage-sensitive fluorophores

Investigating substrate inhibition of enzymes encapsulated within HK97 virus-like particles

Pièce de résistance: Reviving penicillin G against methicillin-resistant Staphylococcus aureus

Polyphenols and phenolic acids reverse uropathogenic Escherichia coli quiescence

Restoring biodiversity to a dying planet

Analysis of the effect of Alzheimer’s disease therapeutics on mitoNEET expression

Investigation into the thermal activation of 15-lipoxygenase-2

Tracking antibiotic resistance plasmids in E. coli

Understanding how MitoNEET contributes to oxidative stress

Solving the phase problem in X-ray crystallography using an ab initio hybrid input-output algorithm

Phosphonated xanthene fluorophores: Synthesis, spectroscopy, and imaging applications

Assembling split inteins for escape from kanamycin resistance protein

Distinct states of MmpL3 in lipid transport across the mycobacterial inner membrane

Using CRISPR/Cas9 editing to probe the function of C. elegans VPS-26