ACS Spring 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

American Chemical Society

New Reactions & Methodology

Diastereoselective addition of prochiral nucleophilic alkenes to α-chiral N-sulfonyl imines

Silacycle-templated intramolecular Diels–Alder cyclizations for the diastereoselective construction of complex carbon skeletons

Rh(II)-catalyzed fluorination and alkynylation of oxonium ylides : Construction of cyclic quaternary carbon centers

Repurposing π electrophilic cyclization/Dealkylation for group transfer

Synthesis of S,S-dioxooligothiophenes and S,S-dioxooligothienylenevinylenes

Domino Michael/Mannich reaction of N-sulfinyl metallodienamines

Accelerate your DOE and HTE experiments: 3 independently controlled temperature zone heating & reaction block in a single SBS-sized footprint as well as a 384/1536 format plate sealing system

General synthesis of cyclopropanols via organometallic addition to cyclopropanone equivalents: Application to the formation of enantioenriched alkylidenecyclobutanones

Homoaldol reactions of 1,2-cyclohexanedione

Reactivity survey and purification method development for ionic liquid based bioconjugation

Synthesis of "non-natural" complex molecules through the application of photochemistry and transition metal catalysis and their use in bioactivity prospecting

Synthesis of aziridine alkaloids and their potential use as therapeutic agents

Nickel-catalyzed 1,2-carboamination of alkenyl alcohols

Pd-Catalyzed O-Selective Alkylation of 2-Quinolinones

Diastereoselective oxidative addition at carbon: Applications for chiral derivatization

Enantioselective synthesis of cyclopropanone equivalents and application to alkylidenecyclopropanes as precursors of β-amino acid derivatives

Catalyst-controlled regioselective trifluoromethylations of arenes and hetero arenes

Bismuth (III) chloride catalyzed multicomponent synthesis of substituted hexahydroimidazo [1, 2-a] Pyridines

Site-Selective Pyridine Functionalization via Nucleophilic Additions to Activated Pyridiniums

Heterodihalogenation of alkenes and dienes

Sustainable one-pot synthesis of S-aryl dithiocarbamates using diaryliodonium salts

Boron Lewis acid-catalyzed regioselective hydrothiolation of conjugated dienes with thiols

Organocatalyzed radical alkylation reactions using phenyliodine(III) dicarboxylates

Novel N–S electrophiles enable nickel-catalyzed 1,2-arylthiolation of unactivated alkenes

Regioselective alkylation of 2,4-dihydroxybenzaldehyde and 2,4-dihydroxyacetophenone

Catalytic PIII/PV oxidation-reduction condensation for amide coupling and activation

Different ring opening reactions of vinylcyclopropanes

Allosteric activation in radical catalysis enabled by proton-coupled electron transfer

Pyridinium salts as electrophiles in Morita-Baylis-Hillman reaction: The synthesis of vinylhydropyridines via regioselective dearomatization

Synthesis of aryl sulfides by metal-free arylation of thiols with diaryliodonium salts

Formation and reactivity of benzyne intermediates under photochemical conditions

Experimental and computational kinetic analysis of the nucleophile-induced retro-[4+2] fragmentation of ylidenenorbornadiene dicarboxylate diastereomers

Borazine masked fluoroalkyl synthons for the synthesis of fluorinated epoxides and subsequent rtsformations

From simple heterocycles to complex carbacycles: Exploiting tandem dipolar cycloadditions

Bioorthogonal hydroamination of strained and push-pull-activated linear alkynes

(Ultra-)High-throughput experimentation and its application in discovery and optimization of an amine–acid esterification

Metallooxaziridines for the stereoselective aziridination of alkenes

Metallooxaziridines for the amination of alkenes through remote C-H activation

Understading diazirine cycloadditions: Novel methods for the selective cyclopropanation of alkenes

Visible light photoredox catalyzed functionalization of alkenes with 1,3-dicarbonyls

Development of sequence defined oligomers using photo-SPAAC

Development of highly tunable reagents for rapid deoxyfluorination

Gold(1)-catalyzed synthesis of 1H-isochromenes, naphthoquinones, and isoquinolines

Modular synthesis of lactam-fused cyclopropanes enabled by underexplored diazo reagents

Microwave irradiated palladium-catalyzed cascade type cross coupling of phenols and halides for the synthesis of polyphenolic ethers

Readily accessible vicinal diols for a kinetic study of the Corey-Winter olefination

SF6 as pentafluorosulfanylation reagent – Photoredox catalytic pentafluorosulfanylation of α-substitued styrenes

Photo-mediated ring contraction of saturated heterocycles

Development of an allenyl-cross metathesis reaction

Development of novel carbocyclic nucleosides as selective antivirals

Synthesis and evaluation of sulfonylcyclopropanols as modular cyclopropanone and homoenolate equivalents

Computational insights into enantio- and diastereodivergent dual transition metal catalysis: Dispersion/steric effects on stereocontrol and regulation of stereochemically dynamic intermediates

Theoretical calculation of the cage formation mechanism of polyhedral oligomeric silsesquioxane

Ketone hydrosilylation studies using a carbodiphosphorane catalyst

Arenes and diazoalkenes in 1,3-dipolar cycloaddition: An unexplored chemical space

A3B meso-(4-carboxyphenyl) porphyrin derivatives: Facile synthesis and diverse photochemical applications in complex reaction media

Regiodivergent selenol-enes using light or rhodium

Alkylboronate nucleophiles development in undegraduate research

Four faces of one compound: Transformations of isoindolinone-derived N(acyl) ketimines

Enhancing the leaving group ability of alkyl fluorides: I/F exchange reactions mediated by LiI

Nickel-catalyzed domino cross-electrophile coupling dicarbofunctionalization reaction to afford vinylcyclopropanes

Asymmetric pyrene-fused pyrazaacenes and pyrazinocyanines through the Green oxidation of 2,7-di-tert-butylpyrene

Ylidenenorbornadiene carboxylates (YNDs): Experimental kinetic analysis of a nucleophile-induced retro-[4+2] fragmentation

Metal-free direct chlorodifluoromethylation of arenes and heteroarenes utilizing a hypervalent iodine EDA complex under visible light

Transition Metal-Free Regio- and Stereo- Selective trans Hydroboration of 1,3-Diynes: Phosphine Catalyzed Access to Borylated 1,3-Enynes

Bridgehead oxidation of (4+3) cycloadducts derived from oxidopyridinium ions

Design and synthesis of novel unnatural amino acids and their application in creating antibiotic polypeptides

Regioselective radical amino-functionalizations of allylic alcohols via dual catalytic cross-coupling

Development of highly active bifunctional (benz)imidazolyl-palladium catalysts for application in sustainable cross-coupling reactions

Bench-stable N-quaternized ketene N,O-acetals – an underexplored class of reagents for organic synthesis

Synthesis of structurally novel carbamates and ureas derived from the Curtius rearrangement

Efficient synthesis of cyclopropylacetylene, a crucial synthetic intermediate for efavirenz using chlorinating reagents ( PCl5 and Ph3PCl2)

Organocatalytic cis phosphinoboration of 1,3-diynes

Intramolecular tetrazine ligation with α,β-unsaturated carbonyls: Organic methodology, reaction kinetics, DFT calculations, and chemical biology applications

Synthetic and mechanistic studies towards catalytic syntheses of allenes

Enolate or carbanion: Exploring the carbanion character in boron enolates towards the direct aldolization of glycolic acid

Preparation of fluorinated epoxides by fluoroalkylation of carbonyl electrophiles

Preparation of functionalized alkenyltrifluoroborates compounds via hydroboration of terminal alkynes and applications to cross-coupling reactions

O-difluoromethylation of carboxylic acids with CF2 carbene and [2+1] cycloadditions with CFBr carbene: New methods of dihalocarbene incorporation into organic molecules

Efforts of using seven and more membered cyclic anhydrides – in Castagnoli-Cushman reaction

Structurally diverse bench-stable low-valent nickel pre-catalysts: A practical toolkit for in situ ligation protocols

Annelated semibullvalenes: From the cope-rearrangment towards netural jomoaromatics

Titanium mediated synthesis of cyclobutanones

Markovnikov halo-imidoxidation of alkenes via an organocatalytic radical generation from phenyliodine(III) bis(3-halopropionate)s

Sulfuric diamides as substrates in bigginelli reaction

Monosubstituted 3,3-difluorocyclopropenes as bench-stable reagents

Silyloxymethanesulfinate for desulfinylation and sulfonylation

S-M cross-coupling of esters by selective O–C(O) cleavage mediated by air- and moisture-stable [Pd(NHC)(μ-Cl)Cl]2 precatalysts

Amination of hydroxyfluorophores using a Smiles rearrangement strategy

Copper-catalyzed synthesis of benzothiazole derivatives from phenols and alkyl halides

How conditions influence the reactivity and selectivity of oxoammonium salt-based oxidants

Transition metal-free trans semireduction/phosphinoboration of alkynes

Component variation in oxa-Michael Ugi-Smiles reactions

Studies on [1,2]-carbon to carbon silyl migration of α-hydroxy allyl silanes: A new access to α-silyl ketones and aldehydes

Synthesis of illudalane sesquiterpenes by regioselective diyne-alkyne cyclotrimerization

Methodology optimization for the synthesis of novel carbazole derivatives utilizing the Chan-Evans-Lam coupling reaction to target antibiotic resistance

‘Phosphate-ISES’ (in situ enzymatic screening)- a new platform for study emerging transformations

Synthesis of conformationally restricted β-gem-difluorinated pyrrolidines and piperidines

Diastereoselective synthesis of functionalized 2-diazo-1,5-dicarbonyl compounds via Lewis acid catalysis

Tetrazene-based bioconjugation in ionic liquids