The shock in the burn victim is due to the combination of the hypovolemic shock and the cells  shock, which is characterized by specific microvascular and hemodynamic alterations1 .  Burn trauma stimulates the release of inflammatory mediators, which will cause systemic  inflammatory response, resulting in increased vascular permeability both in healthy and  pathological tissue1 .  In burn patients the brain is severely impaired2 ; this correlates to high mortality.  Under normal conditions, the blood brain barrier regulates the passage of molecules, which enter  into the brain tissue; this regulation, under conditions of systemic inflammatory response, sepsis or  severe burn, is severely impaired because the levels of the systemic inflammatory mediators are  excessive, disproportional and correlated to unfavourable outcomes.  The increased permeability of the brain microcirculation determines the extravasation in the brain  tissue of many molecules, such as albumin, exudate and inflammatory cells. These events cause  neuronal damage3 , cerebral oedema4,5and can determine an increase of the intracranial pressure6 ,  which is a fatal complication because its intensity and duration are linked to unfavourable outcome.  Moreover, pro-inflammatory mediators can cause the breakdown of the brain blood barrier, causing  the activation of microglia cells and the astrocytes, which respond with the release of others  inflammatory mediators, determining a massive neuroinflammatory response, leading to cerebral  oedema. Based on these premises, it is assumed that in burn patients there may be brain suffering as  the result of increased intracranical pressure.  Objective: studying the incidence of intracranical hypertension in the severe burn victim.  Method: we made use of the measurement of the diameter of the optic nerve7 , by considering a cutoff of 5 mm8 . By using the doppler effect, we have measured the systolic and diastolic flow  velocity, the average speed and the pulsatility index of the middle cerebral artery9,10,11 .  Data analysis: the evaluation of the intracranical incidence has been studied on a total of 20  patients arrived in intensive care within 8 hours from the injury, at the time 0, 24, 48, 96 hours with  burns that affected more than 60% of the body surface. The diameter of the optic nerve  (ONSD)>5mm is considered of intracranial hypertension (ICP)>20 mmHg. Are considered to be  pathological pulsatility index (PI) >14, mean flow velocity (Vm)<30 cm/sec, diastolic flow velocity  (Vd)<20 cm/sec. The combination of at least two pathological values out of the three has been  considered highly suggestive of endocranial hypertension. Conclusions: collected data showed that in any patient has been found a significant alteration of the  studied parameters, suggesting that, even in the event of an increase of inflammatory status in  severe burn patients, the intracranial pressure is still at physiological levels

P.005 Intracranial pressure incidence on severe burns patient

Dear friends and colleagues,

We will be pleased to welcome you in Turin (Italy) for the 19th European Burns Association´s Congress in 2022. Italy is honored to hold the meeting of the European Burns Association for the second time, after Verona in 1995. Turin is easily reachable from everywhere in Europe, either travelling by car, train or choosing flight connections. During the meeting, held in the renewed industrial center of the main Italian historical automotive factory (i.e. Lingotto-FIAT), we will meet international burn specialists, focusing on standards of care, progresses in burn treatment, strategies to face disaster situations, with a special attention to education of younger colleagues. However, in your spare time, you might enjoy the sweet days of Italian late summer, simply wandering in the green parks and gardens along the two rivers which cross the city, or you might decide to discover the numerous art galleries, churches, palaces, libraries, walking across elegant squares and large boulevards, passing through centuries of art and history; finally, you may choose to immerse yourself in some of the most exciting museum experiences, such as the Cinema Museum and the Turin’s Egyptian museum.

Looking forward to seeing you all in Turin for the 19th European Association´s Congress in 2022!
Maurizio Stella, Congress President, Turin Burn Centre