Objectives
Burn injury causes significant morbidity, functional impairment and disfigurement. Reducing the impact of such injury has led to early surgical intervention and methods to preserve or replace dermis where possible to reduce scar contracture. Enzymatic burn wound debridement has been proposed to preserve dermis, reduce the amount of burn requiring skin grafts and reduce time to treatment.  The objective of this study is to present a systematic review of the role of enzymatic debridement in burn treatment compared to standard of care (debridement and skin grafting) in adult patients with burns.
Methods
A systematic review of randomized controlled and case-control studies reporting and comparing healing outcomes of enzymatic debridement with the standard of care, published on Embase, Medline, PubMed, Google Scholar and Cochrane databases in the period from 1946 until August 2021 was performed. Relevant studies were extracted and analysed with the help of Review Manager Version 5.4.1, The Cochrane Collaboration, 2020. The systematic review was registered with the International prospective register of systematic reviews (PROSPERO) with registration number CRD42021283286.
Results
The database search identified thirteen articles that met the inclusion criteria. Of these, four were systematic reviews, one a consensus document, one randomized controlled trial, five non-randomized prospective studies and two were retrospective reviews. A combined number of 441 patients were included. The average age of patients in the enzymatic debridement intervention group was 42 years and in standard of care group 48 years. Nexobrid application average time was one day. The combined mean total body treated mean surface was 6.5%. Studies investigating Nexobrid mention the combined average success of debridement of 82.8%. Overall, Nexobrid reduces time to treatment, need for surgery and shortens hospital stay.
Conclusion
This systematic review presents the current data supporting Nexobrid usage for enzymatic debridement of partial thickness to deep dermal burns. Moreover, it also discusses trends and directions for further research in this field. Further randomized controlled trials or feasibility studies are warranted. The rrelevant areas of future research with Nexobrid use include reduction of local inflammatory response, optimization of perfusion and drainage due to reduced posttraumatic oedema, its role in preventing compartment syndrome, dermal layer preservation, patient satisfaction perspective, role in mass casualties and systemic response after enzymatic debridement.

**Objectives**
Burn injury causes significant morbidity, functional impairment and disfigurement. Reducing the impact of such injury has led to early surgical intervention and methods to preserve or replace dermis where possible to reduce scar contracture. Enzymatic burn wound debridement has been proposed to preserve dermis, reduce the amount of burn requiring skin grafts and reduce time to treatment.  The objective of this study is to present a systematic review of the role of enzymatic debridement in burn treatment compared to standard of care (debridement and skin grafting) in adult patients with burns.
**Methods**
A systematic review of randomized controlled and case-control studies reporting and comparing healing outcomes of enzymatic debridement with the standard of care, published on Embase, Medline, PubMed, Google Scholar and Cochrane databases in the period from 1946 until August 2021 was performed. Relevant studies were extracted and analysed with the help of Review Manager Version 5.4.1, The Cochrane Collaboration, 2020. The systematic review was registered with the International prospective register of systematic reviews (PROSPERO) with registration number CRD42021283286.
**Results**
The database search identified thirteen articles that met the inclusion criteria. Of these, four were systematic reviews, one a consensus document, one randomized controlled trial, five non-randomized prospective studies and two were retrospective reviews. A combined number of 441 patients were included. The average age of patients in the enzymatic debridement intervention group was 42 years and in standard of care group 48 years. Nexobrid application average time was one day. The combined mean total body treated mean surface was 6.5%. Studies investigating Nexobrid mention the combined average success of debridement of 82.8%. Overall, Nexobrid reduces time to treatment, need for surgery and shortens hospital stay.
**Conclusion**
This systematic review presents the current data supporting Nexobrid usage for enzymatic debridement of partial thickness to deep dermal burns. Moreover, it also discusses trends and directions for further research in this field. Further randomized controlled trials or feasibility studies are warranted. The rrelevant areas of future research with Nexobrid use include reduction of local inflammatory response, optimization of perfusion and drainage due to reduced posttraumatic oedema, its role in preventing compartment syndrome, dermal layer preservation, patient satisfaction perspective, role in mass casualties and systemic response after enzymatic debridement.

P.034 The impact of Nexobrid in the treatment course in adults with partial thickness burns compared to standard of care – a systematic review

Dear friends and colleagues,

We will be pleased to welcome you in Turin (Italy) for the 19th European Burns Association´s Congress in 2022. Italy is honored to hold the meeting of the European Burns Association for the second time, after Verona in 1995. Turin is easily reachable from everywhere in Europe, either travelling by car, train or choosing flight connections. During the meeting, held in the renewed industrial center of the main Italian historical automotive factory (i.e. Lingotto-FIAT), we will meet international burn specialists, focusing on standards of care, progresses in burn treatment, strategies to face disaster situations, with a special attention to education of younger colleagues. However, in your spare time, you might enjoy the sweet days of Italian late summer, simply wandering in the green parks and gardens along the two rivers which cross the city, or you might decide to discover the numerous art galleries, churches, palaces, libraries, walking across elegant squares and large boulevards, passing through centuries of art and history; finally, you may choose to immerse yourself in some of the most exciting museum experiences, such as the Cinema Museum and the Turin’s Egyptian museum.

Looking forward to seeing you all in Turin for the 19th European Association´s Congress in 2022!
Maurizio Stella, Congress President, Turin Burn Centre