Chronic lymphocytic leukemia (CLL) is a malignant lymphoproliferative disease characterized by the accumulation of immature monoclonal lymphocytes in blood cells, bone marrow, spleen and lymph nodes. Patients with leukemia manifest different types of skin lesions that occur in about 25% of cases. These lesions can be divided into a) specific lesions, b) cutaneous manifestations closely related to the disease but without a leukemoid infiltrate and c) associations with various dermatologic conditions. Lichen planus (LP) is an inflammatory skin condition with characteristic clinical and histopathological findings. The eruptive variant of LP, also called exanthematous or generalized LP, has rarely been reported in literature in adults. We report a case of lichen planus - like eruption as the associated skin disease of CLL. A 52-year-old caucasian female patient presented to the dermatology clinic for rapidly spreading, disseminated, erythematous, flat-topped, polygonal papules and macules; pruritic lesions that appear over the trunk and all four extremities. The disease started manifesting approximately one month prior to the evaluation. Her past medical history is notable for B-cell chronic lymphocytic leukemia since 2019 without specific haematological treatment. For a definite diagnosis, a skin biopsy was performed and histopathological examination revealed changes that led to the diagnosis of lichen planus. The differential diagnosis implied the distinction between a considerable number of diseases, especially specific lesions (leukemids). The patient has received various topical and systemic treatments with a slight improvement. Therefore, clinicians need to be aware of the diversity of skin manifestations that can occur as CLL-associated, including the lichen planus lesions.

ESDR067 - Eruptive lichen planus associated with the chronic lymphocytic leukemia: a case report

The scientific meeting of the European Society for Dermatological Research (ESDR) is held yearly, usually in September. With an international attendance of more than 1000 skin scientists from around the globe, the four-day event includes short oral presentations from peer-reviewed abstracts, keynote lectures from international experts, sponsored symposia, satellite programs, educational events as well as an important focus on posters, networking and building collaborations amongst scientists. For more information about this year’s meeting visit our website.