This study was conducted to determine the characteristics of GPP flares and current treatment landscape among patients with GPP in the CEE region. Eligible cases (N=57) that met GPP diagnosis criteria (centre of excellence or ERASPEN) and had follow-up/treatment in the last 10 years were collected from 10 centres. Case report forms were used to collect patient demographics; characteristics of last and most severe flares; treatment and outcomes. Median age at disease onset was 57 years (range 0–84); 59.6% were female. Median flare frequency was 0.7 flares per year; 57.9% had a history of plaque psoriasis. Clinical characteristics of last and most severe flares (for 33 patients last flare was the most severe) were: GPPGA total score 3 or 4 (50.0%; 77.8%); median total body area involved (50.0%; 70.0%); required hospitalisation (77.2%; 91.0%); median duration of hospitalisation, if required (2.0 weeks; 2.0 weeks); elevated C-reactive protein (72.7%; 84.9%); fever >38°C (33.9%; 40.7%). The most frequently used therapies were retinoids (n=38), PUVA/UVB (n=23) and methotrexate (n=22), which were effective (complete response or >90% reduction in skin lesions) in 55.3%, 26.1% and 31.8% of cases, respectively. Anti-TNFs (n=9) and other biologics (n=15) were effective in 33.3–100% of cases, with individual therapies used in 2–5 patients each. Treatments should not be compared as time to achieve skin clearance and duration of response are not considered. Our findings highlight the substantial clinical burden associated with GPP and high unmet need for treatments that provide rapid and sustained skin clearance.

ESDR110 - Characteristics and management of generalized pustular psoriasis (GPP): experience from the Central and Eastern Europe (CEE) GPP Expert Network

The scientific meeting of the European Society for Dermatological Research (ESDR) is held yearly, usually in September. With an international attendance of more than 1000 skin scientists from around the globe, the four-day event includes short oral presentations from peer-reviewed abstracts, keynote lectures from international experts, sponsored symposia, satellite programs, educational events as well as an important focus on posters, networking and building collaborations amongst scientists. For more information about this year’s meeting visit our website.