Psoriasis vulgaris (PV) is a chronic inflammatory skin disease. Patients with severe PV have higher cardiovascular (CV) morbi-mortality compared to mild PV or general population. However, impact of biological treatments on CV parameters is unclear. The aim of this study was to investigate the differential impact of TNF inhibitors (TNFi) and ustekinumab (UST) on morphometric and functional parameters of atherosclerotic disease in severe chronic PV. In this parallel cohort monocentric study, CV parameters including aortic stiffness (AS), carotid stiffness (CS), intima media thickness (IMT) and carotid distension (CD) were prospectively assessed by high-definition ultrasound and arterial tonometry in 29 severe PV patients with increased CV risk profiles, receiving TNFi or UST. Measurements from baseline to M18 were used, along with Psoriasis Area Severity Index (PASI). AS increased in UST patients while decreased in TNFi patients, with a significant differential increase (+1.60 m/s, p<0.03). CS increased in UST patients and decreased in TNFi groups (+1.15 m/s, p<0.05). CD decreased significantly with UST and increased with TNFi (-3.82 kpa-110-3, p<0.04). IMT increased in both groups, more importantly in the UST group. Mean PASI improvements in TNFi and UST groups were respectively 73.9%, and 75.4% at M12. The increased AS and hypertrophy of large arteries under UST compared to TNFi suggest differential impacts of blocking TNF vs. IL-12/IL-23 on arterial remodeling.

ESDR117 - Longitudinal follow-up study of arterial structure in patients with severe psoriasis and treated with ustekinumab or with tumor necrosis factor alpha inhibitors

The scientific meeting of the European Society for Dermatological Research (ESDR) is held yearly, usually in September. With an international attendance of more than 1000 skin scientists from around the globe, the four-day event includes short oral presentations from peer-reviewed abstracts, keynote lectures from international experts, sponsored symposia, satellite programs, educational events as well as an important focus on posters, networking and building collaborations amongst scientists. For more information about this year’s meeting visit our website.