The association between rosacea and skin cancer remains inconclusive with conflicting reports. In this nationwide population-based retrospective cohort study we aimed to determine the risk of skin cancer in patients with rosacea. A rosacea cohort (n = 11,420) was formulated and evaluated from 2010 to 2019. The incidence rate ratios of actinic keratosis, skin cancer (malignant melanoma[MM] and non-melanoma skin cancer[NMSC]), gastric, colorectal, and liver cancer were analyzed in comparison to the matched control group, and multivariable stratified Cox proportional hazards model analysis was conducted. The risk of actinic keratosis was increased in rosacea group compared to the control group (adjusted hazard ratio[aHR], 6.05; 95% confidence interval[CI], 3.63-10.09). The risk of NMSC was also increased (aHR, 2.66; 95% CI, 1.53-4.61). The risk of MM, gastric, colorectal or liver cancer (aHR, 1.69; 95% CI, 0.25-11.37, aHR, 0.81; 95% CI, 0.59-1.10, aHR, 0.91; 95% CI, 0.69-1.18, and aHR, 1.32; 95% CI 0.89-1.95, respectively) was not increased. Our study reveals an increased risk of actinic keratosis and skin cancer, particularly NMSC, in patients with rosacea.

ESDR122 - Increased risk of actinic keratosis and non-melanoma skin cancer in patients with rosacea: A nationwide population-based retrospective cohort study from South Korea

The scientific meeting of the European Society for Dermatological Research (ESDR) is held yearly, usually in September. With an international attendance of more than 1000 skin scientists from around the globe, the four-day event includes short oral presentations from peer-reviewed abstracts, keynote lectures from international experts, sponsored symposia, satellite programs, educational events as well as an important focus on posters, networking and building collaborations amongst scientists. For more information about this year’s meeting visit our website.