We aim compare time trade-off (TTO), EQ-5D-5L and Dermatology Life Quality Index (DLQI) utility measures based on patients’ preferences in atopic dermatitis, hidradenitis suppurativa, pemphigus & psoriasis. Secondary objective is to determine the effect of sociodemographic characteristics that impact utility scores. Four multi-centre cross sectional surveys were carried out between 2014-2022 in Hungary, using paper-based self administrated data collection method. Conventional TTO task with 10 year timeframe was applied to elicit direct health utility. EQ-5D-5L using the Hungarian value set was applied to estimate indirect utility. The dermatology specific utility was generated from DLQI total scores applying a mapping-algorithm. Mean, SD, median, IQR were calculated for TTO, EQ-5D & DLQI utilities. The effect of sociodemographic variables on TTO, EQ-5D & DLQI utility was analysed by tobit regression models. The study reports N=765 responses of patients. Proportion of females was 47.3%, sample mean age was 41.5. Mean (SD) TTO, EQ-5D and DLQI utility values were: 0.83 (0.24); 0.81 (0.22) and 0.77 (0.14), respectively. Median (IQR) scores followed the same order: TTO 0.95 (0-74-1.0) > EQ-5D 0.89 (0.75-0.97) > DLQI 0.79 (0.70-0.86). The mean utility scores in atopic dermatitis, hidradenitis suppurativa, pemphigus and psoriasis emerged as follows: TTO: 0.85; 0.78; 0.72 0.91; EQ-5D: 0.82; 0.76; 0.84 0.81; DLQI: 0.74; 0.75; 0.80 0.80. Regression show that TTO utility is significantly elevated if being higher educated (β=0.15). More severe skin condition predicts lower TTO utility (β=-0.45). EQ-5D utility is higher if being secondary or higher educated (β=0.08 &0.13), full-time employed (β=0.09), lower if skin condition is severe (β=-0.51). DLQI utility was decreased if the respondent is older, female, uses outpatient care service and affected by hidradenitis suppurativa. Our findings suggest, that preference based measures are different from generic/dermatology-specific health state valuations, DLQI scores should be converted to utility with caution.

ESDR138 - Comparative analysis of patient’s direct indirect and dermatology specific utility values in four dermatological diseases

The scientific meeting of the European Society for Dermatological Research (ESDR) is held yearly, usually in September. With an international attendance of more than 1000 skin scientists from around the globe, the four-day event includes short oral presentations from peer-reviewed abstracts, keynote lectures from international experts, sponsored symposia, satellite programs, educational events as well as an important focus on posters, networking and building collaborations amongst scientists. For more information about this year’s meeting visit our website.