In recent years, multiple biologic therapies with various mechanisms of action for the treatment of inflammatory diseases have been developed, including moderate to severe plaque psoriasis. The choice of the optimal treatment for psoriasis can depend on several factors and is strongly influenced by the effectiveness and safety profile of a drug. Thus, following an observational, non-interventional, retrospective study of patients with moderate to severe psoriasis receiving biological treatment with IL-17 inhibitors, we analyzed our experience in evaluating from real data the persistence of anti-IL-17A therapies and to identify the factors that may affect these patients. Our results provide an unbiased and true analysis of the outcome and persistence of these biological agents. Biological therapies prescribed in psoriasis can exacerbate comorbidities, which in turn can influence psoriasis. Therefore, proper management of psoriasis should involve an integrated approach. Thus, various factors interact with each other and can directly and / or indirectly affect the pathogenesis of psoriasis. For example, obesity, female gender, or the existence of psoriatic arthritis are associated with the course of psoriasis and also depend on the patient's age, lifestyle, and concomitant illness. Patients' biological experience also affects the persistence rates of biologic therapies, and this can help both patients and clinicians make treatment decisions. The holistic approach to the psoriasis patient and placing it at the center of our concerns as therapists are generally valid and always relevant goals in trying to reduce the burden of psoriasis.

ESDR164 - Correlations between etiopathogenic factors and persistence of anti-IL-17A biologic therapies in patients with severe psoriasis vulgaris

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