Increased Staphylococcus aureus colonisation is associated with atopic eczema (AE) severity. Reduction of S. aureus levels, especially in AD patients, may led to an improvement in the skin condition. Thus, the aim of a study was to evaluate the reduction od S. aureus biofilm formation, of two emollients for face and body care (no. 19624 and 19625 respectively). They contained complex of two ingredients (oligofructants from Ophiopogon japonicus and acetyl heptapeptide-4). Moreover safety and tolerability of mentioned products were evaluated. Bacterial suspensions of strains Staphylococcus aureus MSSA (83254), MRSA (BH1CC) and two strains of S. epidermidis (RP62A and 1457) were mixed and incubated with several dilutions of tested emollients for 24 hrs, next stained with crystal violet. MTT cytotoxicity in vitro (L929 cells) and irritation potential ex vivo on EpiDerm skin model were measured according to ISO 10993. In addition to this, the severity of AD and occurence of flares-up in children was tested in a preliminary studies in comparison to topical medical treatement. Both emollients reduced S. aureus biofilm formation with different impact on S. epidermidis. Also the tested products did not show skin irritation potential and cytotoxicity in vitro towards L929 cells. In addition to this the preliminary studies demonstrated that after 7 days of emollient therapy reduced severity of eczema was comparable to medical treatement with corticosteroids. Both products were biocompatible with the skin and well-tolerated. They may be considered as an effective Emollient Plus type of devices to reduce flares-up in patients suffering for atopic eczema/dermatitis.

ESDR243 - Targeting S. aureus biofilm with leave-on emollients containing oligofructants and acetyl heptapeptide-4 complex

The scientific meeting of the European Society for Dermatological Research (ESDR) is held yearly, usually in September. With an international attendance of more than 1000 skin scientists from around the globe, the four-day event includes short oral presentations from peer-reviewed abstracts, keynote lectures from international experts, sponsored symposia, satellite programs, educational events as well as an important focus on posters, networking and building collaborations amongst scientists. For more information about this year’s meeting visit our website.