This study aims to understand the relationship between the genetic polymorphisms of IL-1β, COX2 and EP4 and the biochemical parameters of the complete blood count in patients with psoriasis. 63 psoriasis patients were analysed and divided based on PASI: <5 (G1) and ≥5 (G2). Determination of IL-1β (rs16944; A>G), COX-2 (rs20417; G>C) and EP4 (rs4613763; T>C) was performed by endpoint genotyping. A statistically significant value of p<0.05 was considered. Allele A of IL-1β polymorphisms showed a 4.23-fold risk [1.22-14.59] for G2. In G2 were significantly increased values of hemoglobin, mean corpuscular hemoglobin concentration, leukocytes, neutrophils, platelet-lymphocyte ratio, neutrophil-lymphocyte ratio, sedimentation rate, triglycerides, total cholesterol-high-density lipoprotein-cholesterol (HDL-C) ratio and significantly reduced values of lymphocytes, lymphocyte-monocyte ratio (LMR), HDL-C and chlorides. Were also observed significantly increased values of total bilirubin (GG genotype), creatinine (G allele), total cholesterol (TC) (AA genotype), LDL-C (AA genotype) and HDL-C (AA genotype) for IL-1β polymorphism; TC (G allele) and platelets (CC genotype) for COX-2 polymorphism; LMR (TT genotype) and monocytes (C allele) for EP4 polymorphism. In conclusion, IL-1β polymorphism seems to influence the susceptibility to psoriasis severity directly. COX-2, EP4, and IL-1β polymorphisms can modulate biochemical parameters associated with inflammation. These can be used as clinical biomarkers in psoriasis, providing support in therapeutic decisions and the follow-up of patients.

ESDR309 - Interleukin-1β, Cyclooxygenase-2 and Prostaglandin E2 Receptor 4 Genetic Polymorphisms May Modulate Inflammation Influencing the Severity of Psoriasis

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