Erythroderma is a condition of generalized erythema and scaling of the skin. More than 90% of the body surface area are involved in this condition. This is potentially life-threatening and has been associated with high mortality in hospitalized patients.The aim of this case report is to discuss the drug reaction as aetiology of erythroderma and its manifestations.We report a case of a 55-year-old female patient who had a generalized erythema, pruritus, malaise and edema of her face since 7 days before admitted. She had history of hepatitis, diabetes mellitus type 2, and was in oral allopurinol treatment for last 2 weeks. Extensive generalized erythematous plaques and hyperkeratotic scales were observed in the face, neck, chest, arms, legs, back, and gluteal. Laboratory workup revealed peripheral blood eosinophilia, mild hypoalbuminemia, hyperglycaemia, and elevated AST level. She was hospitalized and got treatment with wet dressing by NaCl 0,9% bis in die (BID), dexamethasone intravenously ter in die (TID), topical steroid BID, and VIP albumin. The blood glucose levels were normalized with insulin therapy, the erythema and hyperkeratoric scale was decreased within ten days of hospitalization. She was discharged and given metilprednisolone 4 mg TID orally and cefixime 200 mg BID orally. Erythroderma can be a primary condition, when the cause is unknown, or a secondary condition, caused by known diseases. One of the aetiology of erythroderma is drug reactions. In this case, allopurinol treatment was discharged because patient was suspected as erythroderma due to drug reaction of allopurinol. Protein loss or hypoalbuminemia was related to desquamation and plasma volume was increased which might cause hemodilution and severe edema. The drug reaction may emerges 2 weeks to several months after exposure to the causative drugs. In this case, the patient presented after receiving 2 weeks. We conclude that erythroderma due to allopurinol is the most common cause of drug reaction which need a careful assessment and treatment because of its manifestation that effect the patient’s quality of life.

**Background:** Condyloma acuminata is a sexually-transmitted disease caused by Human Papillomavirus (HPV). In children, it is commonly caused by vertical transmission from the mother or sexual abuse. One of the effective treatments is electrocautery. In this study, we reported an unusual case of a 14-month-old boy with condyloma acuminata.
**Case Report:** A 14-month-old boy presented with bumps on the anal area for the last month. There was also a history of blisters on the anal area three months before. The bumps were skin-colored, cauliflower-like, and increasing in size. Acetowhite test was positive, and he was treated using electrocautery. The biopsy result confirmed condyloma acuminata.
**Conclusions:** Condyloma acuminata in children may occur due to vertical and horizontal transmission. Condyloma acuminata is a sexually-transmitted disease; however, it is challenging in children since there is a possibility of sexual abuse. Electrocautery is one of the effective therapy in managing condyloma acuminata in children and can provide a good outcome.

ESDR423 - Eryhtroderma Due to Allopurinol Drug Reaction

The scientific meeting of the European Society for Dermatological Research (ESDR) is held yearly, usually in September. With an international attendance of more than 1000 skin scientists from around the globe, the four-day event includes short oral presentations from peer-reviewed abstracts, keynote lectures from international experts, sponsored symposia, satellite programs, educational events as well as an important focus on posters, networking and building collaborations amongst scientists. For more information about this year’s meeting visit our website.