Nail apparatus melanoma (NAM) is a subtype of cutaneous melanoma occurring at nail units and belongs to the acral lentiginous melanoma subgroup. Due to its unique anatomical structure to protect acral site, mechanical trauma may have a clinicoprognostic impact on NAM. Therefore, we investigated the clinicoprognostic and histopathological characteristics of NAM according to the presence of trauma history prior to melanoma development. Clinicopathological and follow-up data of patients with NAM according to trauma history were obtained. We included 87 patients with NAM, 21.8% of whom had a previous trauma history. Trauma-related NAMs were more likely to involve toenail (p = 0.040), include high proportion of amelanotic melanomas (p = 0.038) as well as nail bed tumor (p = 0.013), and have longer time interval between the onset of nail change and confirmed diagnosis (p = 0.012). Moreover, survival analysis revealed that trauma-related NAMs more frequently showed progression in general (p = 0.034) and nodal metastasis (p = 0.047) and had worse prognosis in terms of progression free survival (p = 0.004). In conclusion, NAMs with previous trauma have unique clinicoprognostic characteristics. The specific clinicopathological features of NAMs according to trauma indicate that trauma may play a role in melanoma development.

ESDR495 - Clinicopathologic Characteristics of Trauma-Related Nail Apparatus Melanoma: A Comparative Study According to the Presence of Trauma Prior to Melanoma Development

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