Sebum is a well-recognised protection of the skin and minor changes on its composition and quantity impact skin homeostasis. Over production induces skin microbiota dysbiosis in favor of C. acnes proliferation leading to skin homeostasis dysbalance. Mangifera indica extract was traditionnaly used in folk medicine for its antibacterial and antioxidant properties. In vitro studies demonstrated that the main phytomarker identified, mangiferin, was a potent inhibitor agent of lipogenesis. Sebum regulation was evaluated on sebocytes derived from iPS of African, Asian and Caucasian donors and then by analyzing volume of sebaceous glands in skin explants. Genes expression analysis was also performed on sebocytes. Then molecular docking was done between mangiferin and PPARγ. The clinical studies were conducted on 3 cohorts representative of African, Asian and Caucasian skins. Biometric analyses included measurement of sebum level, quantification of porphyrins. Skin microbiota composition was evaluated by New Generation Sequencing techniques. Inhibition of C. acnes lipase activity was assessed in vitro. Inhibition of lipogenesis was evidenced in sebocytes and volume of sebaceous glands was reduced. Global genes expression analysis revealed that FDFT1, PPARG and DGAT2 expressions were down-regulated. Mangiferin interaction with PPARG was confirmed by molecular docking. The clinical studies confirmed the previous results with sebum reduction. The extract showed an inhibition of C. acnes growth in vitro and it was confirmed through reduction of porphyrin. The proportions of two major genera (Staphylococcus and Acinetobacter) were different with a placebo application whereas with the extract, the skin microbiota composition was maintained. M. indica extract proved its global efficacy on all skin types in sebum normalization through PPAR pathway. The reduction of C. acnes lipase activity and the skin microbiota protection conduct to skin homeostasis for an healthier and a better skin complexion.

ESDR578 - Targeting PPARγ pathway and protecting skin microbiota balance for sebum harmonization in all skin types

The scientific meeting of the European Society for Dermatological Research (ESDR) is held yearly, usually in September. With an international attendance of more than 1000 skin scientists from around the globe, the four-day event includes short oral presentations from peer-reviewed abstracts, keynote lectures from international experts, sponsored symposia, satellite programs, educational events as well as an important focus on posters, networking and building collaborations amongst scientists. For more information about this year’s meeting visit our website.