Isiaka A. Owolabi, Cory T. Ludwig and David B. C. Martin<br/>Department of Chemistry, University of Iowa, Iowa City, Iowa 52242-1294<br/> <br/>Photocatalytic radical-mediated strategies have received considerable attention as they are becoming a valuable tool in the synthetic organic community. Various strategies for carbonylation that involve the incorporation of carbon monoxide into organic molecules have been investigated, including the synthesis of esters, amides, and heterocyclic compounds. These new strategies often rely on the generation of an acyl radical as a key intermediate following the direct incorporation of CO into the substrate structure. In this study, the production of the acyl radical in visible-light-induced photocatalytic systems is interfaced with hydrogen atom transfer (HAT) to complete the cyclization process. The ability to selectively form different desired products based on ligand and H-donor combinations provides encouragement for the feasibility under our stoichiometric reaction conditions.

New strategies for photocatalytic metal-catalyzed carbonylation and cyclization

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ACS Fall 2022

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