The past few decades have witnessed organic dithiocarbamates have privileged diverse applications in various areas of research such as synthesis of several building blocks, protecting group in peptide synthesis, anticancer agents, monoacylglycerol lipase (MAGL) inhibitors, along with antimethicillin-resistant Staphylococcus aureus (MRSA) agents. Accordingly, the synthesis of these compounds stands as one of the promising areas of research attracting the interests of synthetic organic chemists. Traditional synthesis of aryl dithiocarbamate compounds often requires stoichiometric and toxic organometallic reagents, harsh reaction condition, expensive ligands, and transition metal catalyst, owing to which they are not desirable due to sustainability. In this regard, hypervalent iodine (III) (HVI) reagents have emerged as readily available, atom economical, bench stable, non-toxic, and scalable reagents for the synthesis of aryl dithiocarbamate are highly sought after. And for the synthesize of aryl dithiocarbamates. Herein, we have proposed an efficient and sustainable method, one-pot three-component coupling between diaryliodonium triflate, carbon disulfide, and cyclic and acyclic aliphatic amines resulting in the formation of biologically active <i>S</i>-aryl dithiocarbamate.

Sustainable one-pot synthesis of <i>S</i>-aryl dithiocarbamates using diaryliodonium salts

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Sustainable one-pot synthesis of S-aryl dithiocarbamates using diaryliodonium salts