Ulcerative colitis (UC) occupies one of the top places in the structure of gastrointestinal tract diseases. In recent years, there has been an upward trend in the incidence and prevalence of UC worldwide. The etiology of the disease remains unknown, and the pathogenesis is not well understood. This leads to further study of the etiology and pathogenesis of UC, improvement of treatment methods.<br/>The study included 25 patients with UC and with lesions of the left colon in the acute phase. The average age of the patients was 43.2 ± 12.3 years. All patients underwent colonoscopy and histological examination of the colon mucosa. The patients were divided into two groups: the first group received the usual treatment (mesalamine, ciprofloxacin, and prednisone) and a general diet, while in the second group, additionally a pectin solution as part of the diet. Patients of group 2 (15 patients) received 400 ml of apple pectin two times a day for four weeks; they followed the diet, as in the first group.<br/>In the vast majority of patients, there was a violation of the frequency of bowel movements, which ranged from 4 - 5 to 15 - 18 times a day. All patients had pain syndrome, while cramping prevailed in 52%, less often aching - in 11%, mainly in the left abdomen - in 76% of patients. After pectin therapy, stool normalization was revealed in 13, reduction in pain syndrome in 15, a decrease in the degree of histological activity in 8 patients (p &lt; 0.05).<br/>Thus, in patients with UC, the inclusion of pectin in the treatment regimen for four weeks has a positive effect, normalizes stool frequency, reduces pain and histological activity in the colon mucosa.

Use of pectin in the therapy of ulcer colitis. Clinical and endoscopic assessment

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ACS Fall 2022

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