This presentation will share several short stories on recent applications of metal-catalyzed transformations at AbbVie. We have developed novel methods for Pd, Cu, and Ni-catalyzed reactions and have used them to prepare pipeline assets. For example, the combination of Pd<sub>2</sub>(dba)<sub>3 </sub>and novel biaryl phosphorinane ligands have been used to prepare an intermediate for ABT-333 as well as to catalyze several highly challenging C-N cross-coupling reactions. A pyrrole ligand was discovered for Cu that catalyzes unprecedented coupling of highly sterically hindered partners. The substrate scope, kinetic and mechanistic studies will be discussed. Finally, a recent discovery of a simple and inexpensive ligand for Ni that can catalyze Suzuki coupling of Lewis basic partners will be discussed.

Highlights from the center of catalysis at AbbVie

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.