Nicotinic acid (NA) is a common component in many skincare and beauty products, making researchers interested in understanding more about its metabolism and potential impacts to humans and the environment. NA can be degraded by harmless, soil-dwelling bacteria and provides model systems for understanding the metabolism of N-heterocyclic compounds. While the metabolism of NA in Pseudomonas putida and Bordetella bronchiseptica has been determined, the pathway has only been hypothesized within Bacillus niacini. In an effort to confirm this pathway, we are interested in determining the substrate for B. niacini NicC. NicC is hypothesized to be a catalyst in step two of the B. niacini pathway. Potential substrates for the pathway are 2,6-dihydroxypyridine (2,6-DHP), 2,3,6-trihydroxynicotinic acid (2,3,6-THP), or 2,6-dihydroxynicotinic acid (2,6-DHNA). However, these compounds are not commercially available, creating the need for syntheses. This work will highlight the syntheses of these intermediates 2,6-DHP and 2,6-DHNA and assays to determine their ability to act as substrates in NA degradation. By recreating the B. niacini pathway in a laboratory setting, the hope is to understand the mechanisms of this pathway as well as being able to determine societal implications that NA might have.

Synthesis and characterization of 2,6-dihydroxypyridine, an intermediate in bacterial nicotinic acid metabolism

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.