Herein, we describe a practical two-step synthesis of an Indolo[3,2-c]quinoline scaffold from substituted 4-methoxyquinolines using Fischer indole method and oxidative aromatization in one-pot under Microwave radiation. With this protocol, a biologically active natural product, Isocryptolepine, and its analogues can be readily and efficiently accessed. Also, this method has been efficiently utilized to generate a series of novel pyrrole-containing derivatives of this heterocyclic system.

Microwave-assisted, two-step synthesis of indolo[3,2-c]quinolines via Fisher indolization and oxidative aromatization

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