Despite an abundance of interest, studying factors that influence neuron signaling remains a challenging field of research. There are several factors that limit researchers from studying neurons, including rapid signaling kinetics, cell health sensitivity, and lack of primary neuron availability. To address these issues, we have developed a model for neuron signaling that uses immortalized non-neuronal cell lines as the biological substrate and non-invasive photocontrol as the signal stimulant. Here, we demonstrate the systems use as an effective model to phototemporally regulate intracellular calcium on a timescale relevant to neuronal calcium signaling.

Photo-controlled serotonin receptor modulation as a model for neuron signaling using non-neuronal cell lines.

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.