A one pot copper-catalyzed annulation reaction of primary amines with ynamide-derived buta-1,3-diynes for the synthesis of 2,5-diamino substituted N-aryl/alkyl pyrroles up to excellent yields has been showcased. A large number of primary amines having reactive functional groups are well tolerated. Notably, sterically demanding anilines and primary aliphatic amines are excellent amine sources. Subsequently, scale up reaction and chemical elaboration of pyrrole derivatives highlight the efficiency of the current protocol.

Cu-catalyzed [4 + 1] annulation reaction: A modular approach to N-Aryl/Alkyl substituted 2,5-diamidopyrroles

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.