Lung cancer has been the leading cause of cancer mortality for decades, with nearly 235,760 diagnosed in 2021, due to its difficulty to diagnose at an early stage. There is an urgent need to improve the current detection and treatment/therapy methods. The goal of this study is to determine whether carbon dots can be used as anticancer agent to kill lung cancer cells. For this purpose, yellow- luminescent carbon dots (Y-LCDs) were synthesized using a one-pot hydrothermal method.  We will discuss the details synthesis procedure we have used for the synthesis of Y-LCDs. We will also discuss the characterization of Y-LCDs using TEM/SEM based microscopic technique, as well as the fluorescence, absorption, and FTIR based spectroscopy techniques. The anticancer properties for Y-LCDS were determined using NCI H-1299 lung cancer cells. Results from the cell assays showed potential of Y-LCDs to kill lung cancer cells. Details of dependent anti-cancer properties and mechanism for possible toxicity will be discussed.

Development of carbon dots based anticancer agents for combating lung cancer

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ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.