Noninvasive wearable sensors provide a unique opportunity for real time monitoring of health conditions in biological fluids. Uric acid is an indicator of hyperuricemia, and abnormal change in its concentration indicate the occurrence of a severe conditions that needs to be controlled on time. Herein we designed a non-enzymatic colorimetric diagnostic tool for the sensitive detection of uric acid in human serum and sweat samples. The sensor is designed by 3D printing mechanism containing biocompatible hydrogels incorporating with highly catalytic ceria nanoparticles (CeO<sub>2</sub>) and 3,3’,5,5’-tetramethylbenzidine (TMB) dye. In the absence of target analyte, colorless TMB can be oxidized to a bluish color with CeO<sub>2</sub>, while the oxTMB can be reduced in the presence of uric acid. Based on redox reactivity, biocompatible hydrogels have been explored to design a colorematric sensing patch for the noninvasive detection of current analyte. Designed sensor was first tested on a paper substrate and later implemented on 3D-printed hydrogel to enable one-step formulation of detection. The optimized diagnostic patch can detect up to 7.65 ppm of uric acid in a very short time (less than 10 min) to hold the potential for point of care testing. In future, designed sensing platform can be further customized to detect multiple analytes to meet the end users needs for rapid diagnostic of real time diseases.

3D-printed wearable sensor for the rapid detection of uric acid

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