This lecture will describe recent progress in development of backbone-modified peptides intended to mimic information-rich surfaces displayed by specific conformations of natural polypeptides.  Backbone modification is achieved through replacement of one α-amino acid residue or more with a β-amino acid residue.  The β residue can display the natural side chain, or this residue can be preorganized via a ring. The resulting α/β-peptides can inhibit specific protein-protein interactions, or they can augment signaling through polypeptide-activated receptors. Merits of the α/β-peptides include enhanced resistance to proteolysis and the ability to transmit signals that differ subtly from those of a prototype α-peptide.

Impact of backbone modifications on informational properties of polypeptides

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.