1,2,3-Triazoles have several biopharmaceutical functions such as antiviral and antiallergic behaviors. The process to create these molecules involves the cycloaddition of an azide, an alkyne, and a catalyst. However, many catalysts contain rare metals that are costly and dangerous. The purpose of this research was to determine if copper is a viable replacement for these metals, and if so what reaction conditions are the most favorable.<br/>The copper catalysts were examined under a few different conditions. These were reactions containing solvent, neat (no solvent), with heat, and at room temperature. Additionally, the effect of the charge of copper was investigated. The importance of these variables was to find the most green combination of conditions; for example, a reaction not requiring solvent or heat would be considered ideal. The products were characterized by melting point, TLC, IR, and GCMS.<br/>The results indicated that copper catalysts provide a high yield of pure product, with neat conditions being the most efficient reactions. Furthermore, it was observed that the cycloaddition reactions can also be run at room temperature. The charge of copper does not appear to affect the reaction, although the stability and sterics of the anion attached to the copper do.

Comparing copper catalysts in the synthesis of 1,2,3-triazoles via click chemistry

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.