Retinoic acid receptor-related orphan receptor γt (RORγt) is a transcription factor that regulates the differentiation of naïve T cells into IL-17-producing Th17 cells. Modulating RORγt to block production of proinflammatory IL-17 cytokines has been investigated as an approach for treating autoimmune diseases. In this presentation, we will describe optimization of pyrazolecarboxamide RORγt modulators discovered at Janssen. Our studies culminated in identification of selective, orally bioavailable RORγt inverse agonists that demonstrate potent activity across in vitro assays and dose-dependent suppression of IL-17A in an acute mouse model.

Discovery of pyrazolecarboxamide RORγt inverse agonists at Janssen

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.