Asymmetric catalysis allows for the generation of specific stereoisomers required for modern therapeutic development. Finding alternates to traditional chiral ligands has been of growing interest in recent years, especially toward catalysts that utilize biologically stabilized catalytic complexes. Copper(II) complexes have been readily generated that utilize the chiral nature of DNA for asymmetric processes, including a range of Lewis acid catalysts. Here, we explore the Lewis acid-catalyzed Michael addition, Diels-Alder, and Friedel-Crafts reactions supported by copper(II) complexes of phenanthroline and a range of phenanthroline derivatives that showcase strong affinity toward a protein host. These protein/copper-complexes will be assessed for their ability to support Lewis acid catalysis and the enantioselective nature of these processes.

Copper (II) complexes for Lewis acid-promoted, protein-dependent hybrid catalysis

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ACS Fall 2022

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