A major problem with patient treatments using anticancer compounds is accompanying bacterial infections which makes more information on how such compounds impact bacterial growth desirable. In the following study we investigated the growth effects of an anticancerous non-toxic Schiff base oxidovanadium(V) complex (N-(salicylideneaminato)-N’-(2-hydroxyethyl)ethane-1,2-diamine) coordinated to 3,5-di-tert-butylcatecholato ligand on a representative bacterium, Mycobacerium smegmatis (M. smeg). We prepared the Schiff base V-complexes as reported previously and selected a few complexes to develop a V-complex series. Biological studies of M. smeg growth inhibition were complemented by spectroscopic studies using UV-vis spectrophotometry and NMR spectroscopy to determine which complexes were intact under biologically-relevant conditions. We specifically chose to examine 1) the growth effects of Schiffs base oxidovanadium complexes coordinated to a catechol, 2) the growth effects of respective free catecholates on M. smeg, and 3) to identify complexes where the metal coordination complex was more potent than ligand alone under biological conditions. Results from these studies showed that the observed effects of Schiff base V-catecholate complex is a combination of catechol properties including toxicity, hydrophobicity and sterics.

How do anticarcinogenic vanadium-compounds effect bacterial infections?

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