High-resolution mass spectrometry has played a central role for exploring cellular signaling, epigenetic mechanisms and chromatin regulation.  We are especially interested in understanding how protein and nucleic acid modifications mediate their canonical functions and regulate nuclear processes. Mass spectrometry has become an unparalleled tool in the analysis of these biological molecules and allows us to obtain quantitative information about modifications as well as their co-occurrence. These modifications are critical for nuclear stability and transcription; and dysregulation of these pathways underlie several human diseases such as cancer. Here we describe our latest efforts to improve the detection and quantification of both highly modified proteins such as histones, as well as our initial work to describe the modification types on RNA molecules.

Mass spectrometry based approaches for interrogation of epigenetic and epitranscriptomic modifications

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.