The use of nanomaterials for the delivery of cargo, has been extensively explored to better understand the chemical biology in local environments. Moreover, spatiotemporal control over the cargo release is extremely important to reduce off-target effects. In previous work, we developed a NIR-Light-responsive nanoparticle for the release of small molecule chemotherapeutics <i>in vivo</i>. In this study, we have created a library of light-responsive nanoparticles to optimize the encapsulation and release of a variety of molecules with different chemical and physical properties. In addition to the photolabile moiety of the nanoparticle we incorporated a photo-stable NIR-II molecule that can be used to track the nanoparticles through photoacoustic imaging. The library of nanoparticles and cargo were then used to treat multiple murine cancer models by releasing the encapsulated chemotherapeutics with NIR-light irradiation.

Optimization of controlled-cargo-release from NIR-light-activatable nanoparticles for <i>in vivo</i> Cargo Delivery

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

Optimization of controlled-cargo-release from NIR-light-activatable nanoparticles for in vivo Cargo Delivery